GE23077-binds-to-the-RNA-polymerase-i-and-i+1-sites-and-prevents-the-binding-of-initiating-elife02450fs003

Description:

Sequence alignments for the β subunits of bacterial RNAP (top twenty-one sequences) and corresponding subunits of human RNAP I, RNAP II, and RNAP III (bottom three sequences), showing locations of GER substitutions in E. coli (black rectangles; sequences from Figure 2A) and S. pyogenes (black and gray rectangles; sequences in Supplementary file 2C). Species are as follows: E. coli (ECOLI), Haemophilus influenzae (HAEIN), Vibrio cholerae (VIBCH), Pseudomonas aeruginosa (PSEAE), Treponema pallidum (TREPA), Borrelia burgdorferi (BORBU), Xylella fastidiosa (XYLFA), Campylobacter jejuni (CAMJE), Neisseria meningitidis (NEIMA), Rickettsia prowazekii (RICPR), Chlamydia trachomatis (CHLTR), Mycoplasma pneumoniae (MYCPN), Bacillus subtilis (BACSU), Staphylococcus aureus (STAAU), Streptococcus pyogenes (STRP1), Mycobacterium tuberculosis (MYCTU), Synechocystis sp. PCC 6803 (SYNY3), Aquifex aeolicus (AQUAE), Deinococcus radiodurans (DEIRA), Thermus thermophilus (THETH), Thermus aquaticus (THEAQ), and Homo sapiens (HUMAN).